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Description
Their primary hormonal action is on the somatotropic axis: more GH, more IGF-1, more protein synthesis, and more favorable partitioning between fat and lean mass

Kalden JR, Schulze-Koops H (2017) Immunogenicity and loss of response to TNF inhibitors: implications for rheumatoid arthritis treatment

This heterogenicity of tumors and the resulting convoluted nature of biomarkers makes personalized cancer treatments challenging, especially considering that combinations of multiple markers correlate with different outcomes compared to single markers

Historical Background and Scientific Context Scientific interest in metabolic regulatory enzymes expanded rapidly during the late twentieth century as molecular biology techniques improved

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Feb 27 2023;2(2):Cd015244
