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Sexual medicine 2 , 4159, doi:10.1002/sm2.27 (2014)

In recent years, in NCT01523808, NCT02195180, and NCT03665441, the combination of red blood cell-encapsulated asparaginase (such as GRASPA and eryaspase) with chemotherapy has been shown to improve the prognosis of patients, indicating its great potential as a second-line treatment [318]

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Navaro et al., 2015)

Individual data were not available for review, but the authors noted that there were very few arrythmias at baseline in their study subjects, and no significant change in dialysis-associated arrhythmias was observed