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This size-based penetration advantage is central to its topical research applications and helps explain why laboratory studies have consistently demonstrated biological activity following topical application models

This is particularly relevant for significant injuries, post-surgical recovery, chronic conditions that have resisted single-agent approaches, or patients dealing with both musculoskeletal and inflammatory components simultaneously

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To confirm that haem-assisted dimerization of PGRMC1 occurs in solution, we analysed the structure of apo- and haem-bound PGMRC1 by two-dimensional nuclear magnetic resonance (NMR) using heteronuclear single-quantum coherence and transverse relaxation-optimized spectroscopy (Supplementary Figs 6b and 7)
However, exogenous applications of MG and NaHS restored these growth parameters (Table 1)

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