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Acknowledgements The authors wish to thank the staff at the Animal Care Facilities at Galleon Pharmaceuticals, Inc

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The CAPTAIN trial series investigated safety and efficacy in this group

Mori et al., 2014), contributing to more than 85% of NAD + synthesis ( de novo pathway and Preiss Handler pathway synthesize NAD + using nicotinic acid (NA) and tryptophan as substrates, respectively, albeit in smaller quantities

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