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Depletion of GSH is strongly implicated in many chronic degenerative diseases such as HIV, autoimmune disease, hypertension, cholesterol oxidation, myocardial infarction, glaucoma, hearing impairment, cataracts, macular degeneration, liver disease, cystic fibrosis, COPD, acute respiratory distress syndrome, asthma, many neurodegenerative disorders, and the aging process itself

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It can also result in confusion and personality changes

Therefore, FOXOs play a crucial role in regulating cellular aging and apoptosis

Biochem Biophys Res Commun (2013) 439(2):25863

In cases where deficiency is caused by pernicious anaemia, patients may need to have injections of the vitamin for the rest of their lives.