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Enzymatic and nonenzymatic antioxidants have important roles in scavenging free radicals and reactive oxygen species (ROS)

All of these 11 patients had normal renal function, and their ages ranged from 17 to 78 years (median, 60 years).11 Pharmacokinetic studies in children and adults suggest an age-dependent half-life of trimethoprim, as indicated in Table 5.12 Table 5: Half-life of Trimethoprim (TMP) in Pediatric Patients and Adults Patients with severely impaired renal function exhibit an increase in the half-lives of both components, requiring dosage regimen adjustment [see Dosage and Administration (2.2)]

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10.1016/J.FOODCHEM.2010.08.066 45 RaskinP.ClementsR