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In addition, 200 mg/kg/d luteolin significantly reduced the low-density lipoprotein content in diet-induced obese mice ( in vitro experiments was similar to the dose used in a previous study ( in vivo experiments used the safe dose of luteolin, i.e., 1/18 the LD 50 (180 mg/kg) ( We used an SPR approach to study the interaction of GPVI with luteolin, and the results suggested a direct interaction between luteolin and GPVI

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doi: 10.1016/j.lfs.2022.120805 32

10.3945/jn.108.100867 119 SuzukiT.TanabeS.HaraH

In Prunus sp., APX and other Asc-GSH pathway enzymes were up-regulated during drought treatment and reduced throughout the recovery period (Sofo et al., 2005b

(2018) investigated the use of curcuminoid nanomicelles (80 mg, orally three times a day) for 4 weeks in patients with mild to moderate ulcerative colitis
