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Khan SS, Grobman WA, Kazi DS

Using propensity matching between the exposure and comparator groups, the authors found that patients exposed to a GLP-1RA had a greater reduction in AUDIT-C scores than unexposed controls, as well as those exposed to DPP-4Is, reflecting a greater reduction in alcohol consumption

Factors Driving Price Differences Why Some Providers Charge Less: Operational Efficiency: Streamlined telehealth model Lower overhead costs Technology-enabled processes Scale advantages Direct Pharmacy Partnerships: Work directly with compounding pharmacies Negotiate volume pricing Eliminate middlemen Pass savings to patients Simplified Service Model: Focus on core medical services No unnecessary premium features Efficient appointment structure Automated processes where appropriate Why Some Providers Charge More: Premium Positioning: Market as luxury service Emphasis on branding Additional amenities Concierge-style care Higher Overhead: Expensive physical locations Large staff for support services Extensive marketing costs Multiple service layers Additional Services: Nutrition coaching bundled Fitness programming Regular body composition testing Extensive support programs Complex Business Models: Multiple profit layers Franchise fees Marketing costs Investor return expectations The medication is identicaldifferences are in service model and business structure, not medication quality

Of note, exendin-phe1 acted as a competitive antagonist against the -arrestin response to GLP-1 itself, suggesting that it might reduce the in vivo -arrestin recruitment by endogenous GLP-1 (Supplementary Fig

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The only publicly traded telehealth platform selling GLP-1s, Hims & Hers (HIMS), also uses this terminology.