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Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia cells in culture by sesquiterpine lactones

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However, under glutamine depletion, AGC1 is crucial for exporting residual aspartate from mitochondria to the cytosol, where it is used for nucleotide synthesis, NEAA production, and the regeneration of NADPH and GSH (Figure 3A)

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HERES THE KEY THING: Glutathione Reductase requires a molecule of NADPH to convert oxidized glutathione to reduced glutathione, which is necessary for the cell to eliminate ROS

In this context, STAT1 binds to a conserved element within the first intron of NAMPT, termed NAMPT-Regulatory Element-1 (NRE1), and enhances its expression, thus driving aerobic glycolysis and initiating expressions of a subset of inflammatory genes in the tumor-associated macrophages stimulated with IFN- [91]