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Astrocytes also modulate the structure and function of the bloodbrain barrier (BBB), a role that has evolutionary roots in glial-controlled vascular regulation observed in primitive vertebrates, with endothelial cell dominance emerging in higher speices 9,10

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Emerging research has elucidated a sophisticated network of miRNAs that fine-tune the expression of key ferroptosis executors (e.g., ACSL4, TFRC) and suppressors (e.g., GPX4, SLC7A11)

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