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This approach not only facilitates the delivery of DSIP into the brain but also highlights the potential of brain-homing peptides as effective carriers for small molecule drugs, targeting brain parenchyma directly and efficiently

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We hope this brief provides a useful starting point for practical strategy design and implementation

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Biochimie (2008) 90(2):22742

Append a colontargeted carbonate to the quinoline nitrogen, forming a prodrug that reduces central exposure, mitigating neuropsychiatric events