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The essential nature of the dendritic arbor as a scaffold for synaptic contacts between neurons suggests that, although continued treatment with ALC appeared unable to ameliorate synaptic signalling deficits that develop later in the course of the symptoms, the underlying structure and connectivity to support improved cognitive function are present

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Cell culture plates were then incubated at 39C for 60 min without CO 2 before measuring oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in the Seahorse analyzer

The process in turn activates other transcription factors (TFs) such as Nuclear factor NF-kappa-B (NFKB1), Nuclear factor erythroid 2-related factor 2 (NRF2), and Transcription factor Sp1, also known as specificity protein 1 (SPI)