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10.1016/j.pharmthera.2020.107705 Pharmacol

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Paparella A., Schirone M., Lpez C.C

Phase I trials have been completed for hematological tumors (NCT02071888) and leukemias (NCT02071927), although no clinical data is publicized

In addition, there is evidence for increased expression of the Nox subunit Nox2 and Nox4 in atherosclerotic arteries, which may contribute to ATII-stimulated oxidative stress during hypertension and human atherosclerotic disease
