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ORAL Treatment of pernicious anemia with high doses of vitamin B12 without intrinsic factor

Oral Dosing Runs Higher Injectable: 200 to 500mcg per dose Oral: 500 to 1,000mcg per dose, once or twice daily, taken on an empty stomach Higher oral doses are used to make up for the fact that the gut absorbs the compound poorly compared to injections

Additionally, NeuN protein levels were decreased (Fig

It modulates GABA receptors allosterically, influences dopamine and serotonin receptor activity, enhances enkephalin levels, and reduces neuroinflammation, all through a single compound

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New England Journal of Medicine 2006;355:20910