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Feed-back regulation occurs as each of the enzymes of -oxidation is inhibited by its own fatty acyl-CoA product, while the reaction is regulated allosterically by the ratios of NADH/NAD + and acetyl-CoA/CoA

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Glucagon and epinephrine reduce the activity of ACC, thereby decreasing fatty acid synthesis

Comments on negative effects of the usage of l-Cys are also summarized after Table 2