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Through its interactions with sulfur and nitrogen metabolism, with ROS and ascorbate via peroxidases and DHAR, with NADPH via GR, with protein thiol-disulfide groups through GRX, and with signaling metabolites and hormones via GSTs, glutathione is an outstanding candidate as a central hub molecule whose status can modulate other signaling pathways

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Effects of N-acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis

Their team also showed that iron overload in the acute phase of SAH leads to oxidative stress and neuronal damage, which can be reversed by the application of DFO (Lee et al., 2010)

Series A, Biological Sciences and Medical Sciences 69, no

Taylor Foreman, National Institutes of Health (NIH), United States Updates Copyright 2021 To, Cao, Yegiazaryan, Owens, Nguyen, Sasaninia, Vaughn, Singh, Truong, Medina, Avitia, Villegas, Pham, Sathananthan and Venketaraman