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In contrast, previous studies have demonstrated that CIPs can be discovered from a much smaller collection of analogs by appending simple electrophilic handles directly onto a ligand of interest 23,24

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coli which have taken up the plasmid will either present as blue, indicating that the plasmid has taken out and the LacZ gene is still intact, or white, indicating that the bacteria has taken up the plasmid, but the g-Block has been inserted into the LacZ gene