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It activates multiple regenerative pathways at once rather than targeting a single mechanism

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[DOI] [PMC free article] [PubMed] [Google Scholar] Licata L, Lo Surdo P, Iannuccelli M, Palma A, Micarelli E, Perfetto L, Peluso D, Calderone A, Castagnoli L, Cesareni G (2020) SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update

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The Glucagon Paradox in Next-Generation Incretin Therapy: How GLP-1, GIP, and Glucagon Receptor Co-Agonism May Amplify Weight Loss Despite Glucagons Hyperglycemic Biology Abstract The development of dual and triple incretin-based receptor agonists represents a major advance in the pharmacologic treatment of obesity, type 2 diabetes, and related cardiometabolic disease