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10.1002/mnfr.201600680 29 GuL.LiN.GongJ.LiQ.ZhuW.LiJ

2025, doi: 10.1007/s12178-025-09990-7

Targeted therapy and ototoxicity Newer therapies aimed at specific cancer types, such as tyrosine kinase inhibitors (TKIs), have been associated with vestibular dysfunction, though their precise ototoxic mechanisms remain under investigation

327 One major mechanism of apoptosis resistance in CSCs is the upregulation of antiapoptotic proteins, including BCL-2, BCL-XL, and survivin, which inhibit the intrinsic apoptosis pathway and prevent CSC death

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