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How It Works GHKCu is a naturally occurring copperbinding tripeptide that penetrates the stratum corneum and signals fibroblasts to produce more collagen, elastin, and glycosaminoglycans while regulating matrix metalloproteinases to reduce excessive collagen breakdown

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This bidirectional relationship highlights how multiple signaling systems converge to regulate pain perception and offers novel opportunities for multimodal analgesic strategies

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Decades of clinical research point to multiple improvements when GHK-Cu is used topically: 1

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