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In dairy cattle, bacterial load on teat skin and bedding increases during the summer and is associated with an increased incidence of mastitis (Hogan et al., 1989a

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Cheng N, Rho JM, Masino SA

These findings are further corroborated by experimental models that show increased NOX4 activity under oxidative stress conditions, including treatment with RAS-selective lethal small molecule 3 (RSL3) or erastin, which have been shown to enhance lipid peroxidation and subsequent cell death (111,112)