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B vitamins support the metabolic pathways that process fats, carbohydrates, and proteins, so adequate B vitamin levels can contribute to a more efficient metabolism

Tirzepatide is a dual GIP/GLP-1 receptor agonist, a peptide that works on two key incretin pathways in the body to regulate blood sugar, reduce appetite, and promote meaningful weight loss

Even if there arent human trials, a lot of people are taking it, and its very seemingly easy to get

For people with B12 deficiency: Yes, indirectly

It is a single small aromatic molecule designed to be membrane-permeable, so in principle it can survive the gut and cross into cells