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Vitamin d is a vitamin which is a kind of nutritional agent (nutritional or metabolic agent)

Lipid dysregulation promotes the pathogenesis of PD by oxidative stress and inflammation, such as proinflammatory lipid mediators of platelet-activating factors, which play a key role in the progressive neurodegeneration associated with -synuclein intracellular traffic in PD

The first comes from the blood, where DNA methylation clocks such as Systems Age from TruDiagnostics, Proteomics-based aging clocks like those from Vero, and RNA signatures read the activity of brain specific aging-associated genes, which is the basis of the NeuroAge panel

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IGF2BP3s role was validated through knockdown/overexpression, patient-derived organoids (PDOs), and xenograft models

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