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Intrinsically, neurons are at risk for oxidative damage as their redox potential remains low due to a poor de novo synthesis of GSH caused by a weak expression of Nrf2 in neurons compared to astrocytes (Bolaos 2016)
If you have autoimmunity, its pretty likely you also have leaky gut
Knowles and Moncada, 1994)
In conclusion, miRNAs play a key role in drug addiction by modulating synaptic plasticity and gene-regulatory programs across reward and stress circuits
