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The trial aimed to evaluate both acute effects on ICP as well as effects over a 3-month time horizon

These numbers explain why a recent poll found that one in eight adults in the US say they use GLP-1 drugs, many for weight loss and others for diabetes

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For context, in a previous Phase 3 trial of Zepbound, the highest-dose group saw a dropout rate of only 6.2% due to adverse events

These results provide a structural framework for understanding class B GPCR activation through hormone binding

In the 2022 SURMOUNT-1 study published in NEJM, three doses of tirzepatide were compared with placebo (1:1:1:1) to determine effects on percent weight change over the course of 72 weeks
