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Conclusion This work compared the metabolic profile of the MDA-MB-231 parental cDDP-sensitive cell line (time course up to 48 h) with that of a derived cDDP-resistant line, the latter characterized by a more than onefold larger IC 50 (for cDDP at 48 h), higher number of PGCCs, a slighter higher activation of the NF-B pathway along with about 50% decrease in the ERK pathway activation

Radiolabeled 6-(2, 3-dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): a potential radiotracer for measuring and imaging MTH1

In the case of the MTR gene the most common mutation is a change of an A for a G at nucleotide position 2756 (A2756G)

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Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB