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Coppe JP, Patil CK, Rodier F, Krtolica A, Beausejour CM, Parrinello S et al (2010b)

Chemical and drug preparation Rotenone and dimethyl sulfoxide (DMSO) were purchased from SigmaAldrich Co., USA

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P.VargasC.SakuraiH.FujiwaraY.HashimotoK.MaokaT.et al (1999)

While numerous compounds have demonstrated efficacy in vitro and in murine models, no phase I or II trials directly targeting NRF2 have been conducted in HCC patients, raising concerns about their applicability in clinical practice

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