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While this has garnered substantial information on where active canonical Wnt signaling is required during development and regeneration, much of the identity of Wnt secreting cells and what combinations of Wnt and Frizzled members are responsible for activating Wnt/-catenin signaling in specific developmental and regenerative processes still remain unknown (Figure 2)

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Therefore, there is an urgent need to build specialized spectral libraries for CDMs but experimentally measuring MS/MS spectra of CDMs at a repository scale remains unrealistic

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The FDA has already approved some of the nasal drug delivery devices (mostly nasal spray) such as Zomig , Astelin , Narcan , Dymista , Advancia , Onzetra, and Nasonex to treat different disorders

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