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Thus, the present invention encompasses host cells into which the recombinant expression vectors encompassed by the present invention have been introduced

meanwhile, the produced Fe 3+ was reduced by GSH into Fe 2+ , accompanying the generation of GSSG (Figures 3A, B)

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According to the 2017 International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy [64], idebenone should be started as soon as possible at 900 mg/day in patients with disease less than 1 year, and treatment continued for at least 1 year to assess response