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PATHOPHYSIOLOGY AND MECHANISMS Migraine is a complex and disabling neurological disorder, more prevalent in women, whose pathophysiology involves neurovascular mechanisms, mitochondrial dysfunction, neurogenic inflammation, and oxidative stress

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Relying on this, tumor-bearing mice with weight loss showed lower GSH levels and higher GSH disulfide/GSH ratios [139]

10.1016/S0140-6736(21)01910-3 Summary Keywords heart-brain axis, myocardial infarction, stroke, stroke-heart syndrome, takotsubo (stress) cardiomyopathy Citation Vancheri F, Vancheri S, Longo G, Vancheri E and Henein MY (2026) Heart-brain axis pathophysiological understanding and clinical impact

Considering that senescent cells can drive the priming of the senescence-associated secretory phenotype (SASP) consisting of pro-inflammatory cytokines such as IL-1/, IL-6, and MCP-1 chemokine, it can be speculated that SHBG may protect against senescence through its anti-inflammatory potential [45]

Li-ESWT and traction therapy are likely to be effective in improvement in penile pain and curvature, respectively