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doi: 10.1016/j.jtherbio.2016.08.003 158 JohnsonJ

The transient opening of mPTP can quickly release Ca 2+

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133 Caspase-1 is a key effector molecule downstream of inflammasome activation and plays a central role in processing and releasing proinflammatory cytokines, such as IL-1 and IL-18

The above findings strongly indicate that oxidative stress, particularly at the level of the mitochondria, plays a central role in the neuronal death that underlies a diverse group of neurodegenerative diseases

Studies indicate that when glutathione levels are low, cells can accumulate more DNA damage after exposure to radiation, and the efficiency of some repair processes decreases