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doi: 10.2147/JIR.S353467 304 ZhangT.TsutsukiH.IslamW.OnoK.TakedaK.AkaikeT.et al

Its skin-brightening properties have garnered attention, but maintaining adequate levels can be challenging due to factors like UV exposure, diet, and stress

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Moreover, two patients discontinued the study after 8 and 9.5 years, one due to a malignant bladder tumor combined with cerebral infarction and the other due to chronic lymphocytic leukemia

Another mechanism is the activation of innocent bystanders, leading to autoreactive T cells, polyclonal activation, and epitope spreading of B cells

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