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Other studies have shown that the other PD drugs acted independently to shape different microbial profiles, which strengthens the rationale for disentangling drug effects from disease signatures ( Prevotella for the rapid-progression cases

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Moreover, activation of PKC with phorbol ester is known to induce 1A -AR phosphorylation, indicating heterologous desensitization, albeit to a much lesser extent than 1B -AR (Vzquez-Prado et al., 2000)

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doi: 10.3390/antiox11091844