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The high-dose long-term safety case carries materially more uncertainty than tirzepatide or semaglutide do at comparable durations

10.1016/j.freeradbiomed.2019.11.021 273 PoloniM.FacchettiD.MaiR.MicheliA.AgnolettiL.FrancoliniG.et al

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They did it using a molecule called SNAC a permeation enhancer that took decades to develop, required a $1.8 billion acquisition of the company that created it, and involved over 9,500 patients across ten Phase 3 trials

This combination of direct fat cell targeting, muscle preservation, metabolic selectivity, and favorable safety profile makes AOD-9604 a distinctive option among metabolic peptides and body composition interventions
