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Future research should focus on clarifying the functional distinctions among its isoforms, elucidating the crosstalk between epigenetic regulation and metabolic signaling, and developing specific PGC-1 agonists for the treatment of metabolic and degenerative diseases

doi: 10.1038/nn.2270

Insulin resistance is correlated with high cholesterol synthesis and decreased cholesterol absorption in men (254)
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2015 doi: 10.1007/s10545-015-9819-7
In healthy populations with adequate levels, the evidence tends to be more heterogeneous, so absolute conclusions should be avoided
