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Minimal immunogenic potential: Long-term studies in rodents and primates report no antibody formation, suggesting a low risk of immune reactions following repeated exposure to the peptide

The placement took effect with FDA's September 29, 2023 update to the list of bulk drug substances nominated for use under section 503A, and FDA's stated rationale included concerns about potential immunogenicity for certain routes of administration and complexities with peptide-related impurities and active-ingredient characterization [16]

It may be that reducing the production of aqueous humor (i.e., beta-blockers, alpha 2-agonists, inhibitors of carbonic anhydrase), promoting drainage through the trabecular meshwork (parasympathomimetics), and through the uveoscleral route (prostaglandin derivatives)

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24 However, GSSG is actively excreted from the cell when its intracellular concentration exceeds the reductive capacity of the cell, as in conditions of oxidative stress