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11 Metabolic Benefits Beyond glucose control, allulose exhibits additional metabolic benefits consistent with GLP-1 receptor activation: Enhanced insulin sensitivity : Improved peripheral glucose uptake and reduced insulin resistance 12 Lipid metabolism : Favorable effects on triglyceride levels and hepatic lipogenesis 13 Anti-inflammatory properties : Reduction in systemic inflammatory markers 14 The GLP-1 Connection Heres where allulose gets interesting for weight management

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Importantly, there is evidence that the effects of both medications varies by disease stage [47, 48], although results from real-world studies of SGLT2is support their effectiveness on cardiovascular and kidney outcomes in broader populations [49, 50]
Both compounds exhibited significant blood glucose reduction in streptozotocin-induced diabetic rats at a dose of 10 mg/kg

10.1056/nejmoa1603827 46 MeurotC.MartinC.SudreL.BretonJ.BougaultC.RattenbachR.et al (2022)
