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Within Section 5 Warnings and Precautions, they further expand on this, also noting that many HLA-B*15:02 positive patients treated with lamotrigine will not develop SJS/TENS, and these reactions can still occur in HLA-B*15:02 negative patients

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doi: 10.1111/febs.1358 276 HuangLKirschkeCPLayYALevyLBLamirandeDEZhangPH