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Oct 2013;30(10):1148-1155

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J Clin Chem Clin Biochem 28 , 359363

It remains to be seen how practical and cost effective daily supplementation of carnitine with carbohydrate is Carnitine and endurance exercise The belief that carnitine is an ergogenic aid for endurance exercise is based on assumptions similar to the weight-loss assumptions: Carnitine concentration in muscle becomes too low to allow the transport of carnitine into the mitochondria to function at a high velocity Oral ingestion of carnitine increases the total carnitine concentration in muscle Any increase in muscle carnitine increases the oxidation rate of plasma FAs and intramuscular triacylglycerols during exercise Any increase in fatty acids will reduce muscle glycogen breakdown and postponing fatigue

The antizyme proteins interact with ODC1 monomers preventing formation of functional homodimers while simultaneously altering the conformation of the monomers so that they are recognized by the proteasome