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Key Takeaways Vitamin B12 is vital for neurological function and DNA synthesis

Vitamin B12 is water-soluble, meaning excess amounts are naturally flushed from the body

whole grains for carbs) can maximize the benefit

In the stomach, hydrochloric acid and enzymes unbind vitamin B12 into its free form

[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing

However, SAH demonstrates activity solely in enzyme-based biochemical assays