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However, subsequent larger studies failed to replicate these results (Yoritaka et al., 2016)

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elegans death was determined by the absence of movement and swallowing, and no reaction after being touched by a platinum wire

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Furthermore, the study hypothesizes a potential interaction of AOD9604 with the beta-adrenergic pathway, especially concerning the beta(3)-adrenergic receptors (beta(3)-AR), which are considered to be key lipolytic receptors found in fat cells