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Description
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One of the key stumbling blocks at this point was that most of the immunoassays then available relied on antibodies sourced from serum collected from immunised animals or humans, called polyclonal antiserum

[DOI] [PubMed] [Google Scholar] Botter SM, Zar M, van Osch GJ, van Steeg H, Dolle ME, Hoeijmakers JH, Weinans H, van Leeuwen JP

It's that serious
