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A prevalence of partial CBS and MTHFR inherited defects is observed in patients suffering from cardiovascular disease (Clarke et al, 1991

NOT B12 DEPOT which is Hydroxocobalamin

If you experience any suspected adverse reactions to vitamin B12 products, report them via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

10.3390/vaccines8040615 20 BuschmannM

But if you come back every week for a month or so you'll notice a big difference in your overall level of energy." So the very first time someone gets a B12 shot they probably won't feel much of an effect, even though they might experience a bit of an energy boost after the very first one, but it usually only lasts for about a week

Long-term safety data in humans is limited