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In 2003, a large double-blind controlled clinical trial was conducted at the Department of Psychology, University of Wales-Swansea et al., UK, with an LOE of 1b

[DOI] [PubMed] [Google Scholar] 35.Barnett C., Costill D.L., Vukovich M.D., Cole K.J., Goodpaster B.H., Trappe S.W., Fink W.J

doi: 10.1186/ar4441

Uric acid comes from the breakdown of purines which are made in the body by normal metabolic processes, or may be present in the diet (Boza 2000

doi:10.1139/v89-234

Increase the dose beyond that point, and efficacy not only wanes, but it reverses