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Notably, there is no direct interaction between the two LepR ECDs, suggesting that receptor dimerization is primarily ligand-dependent, as has been observed for other class 1 cytokine receptors 26

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MWF of the corpus callosum is a robust measure of remyelination: results from the ReBUILD trial

However, numerous studies have shown that, aside from its anti-protease properties, AAT has anti-inflammatory and immune regulatory functions, and some of these functions seem to be independent of the anti-protease activities