what is s-acetyl glutathione S-Acetyl-Glutathione | Xymogen S-Acetyl-L-glutathione:Preparation; Benefits and Side effects_Chemicalbook

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10.1134/S0006297916060018 Biochemistry

In pediatric cancers studied in mouse models, the use of NAC blocks the side effects of cisplatin but may interfere with its effectiveness if used together

[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Yu, T

[DOI] [PubMed] [Google Scholar] 4.Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, Marshall FJ, Ravina BM, Schifitto G, Siderowf A, Tanner CM

This situation would lead to a self-perpetuating cycle, in which the free radicals generated would induce GSH depletion, thus increasing oxidative stress that would reduce antioxidant enzyme levels, which would further reduce GSH synthesis