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Description
Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children

In a study of two patients with refractory lupus who received daratumumab, both patients showed a decrease in disease activity, with downregulation of gene transcripts associated with Tcell activation

These are acidic, and their accumulation causes metabolic acidosis

Symptoms are aggravated by walking or standing for a long duration and improve when sitting down
Allergy risk to cobalt or preservatives (rare) Energy improvement: 24-72 hours Reticulocyte response: 3-5 days Neurological improvement: Weeks to months Hematological normalization: 4-8 weeks Maximum nerve repair: Up to 1 year Injection site reactions (15-20%) Mild diarrhea (initial doses) Itching/eczema (cobalt sensitivity) Transient anxiety (overstimulation) Headache (usually resolves quickly) Serious reactions are extremely rare

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