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BSO (10 M) significantly reduced GSH as measured in cellulo with monobromobimane (mBrB) fluorescence (63 2% of basal
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It activates protein phosphatase 2A, which removes the regulating phosphate group from the liver bifunctional enzyme, the inactivating phosphate from pyruvate kinase, and an inactivating phosphate group from a transcription factor, ChREBP (Carbohydrate Response Element Binding Protein) that activates transcription of genes for fatty acid synthesis in the liver

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