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Effect persistence monitoring: because effects outlast serum presence, endpoint timing should reflect biological process kinetics (days-weeks) rather than serum PK kinetics (hours)

For example, hepatic storage of glycogen allows the release of glucose to other tissue when the need exists (e.g., when plasma concentrations of glucose decrease)

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Oga T, Tsukino M, Hajiro T, et al

Simple, effective, time-tested [1]

Is intravenous the optimal route of vitamin C administration