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A deficiency in vitamin B12 can result in significant health problems, including anemia, neurological disorders, and impaired immune function

This model is supported by evidence from various experimental systems, including the ability of lactate to sustain synaptic function in vitro (Schurr et al., 1988), the cellular localization of relevant transporters and enzymes, and in vivo studies using microsensors that report rapid lactate consumption coupled to oxygen utilization in the tissue parenchyma during activation (Hu and Wilson, 1997)

Pattern across both trials Nausea, vomiting, and diarrhea peaked during dose escalation and tapered during maintenance

Checkoway et al., 2012

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Consequently, this combination allows for a lower effective dose of Levodopa